Louis is the editor-in-chief of Don on the eve of an important meeting with an investor group. He dumps his umpteenth one-night stand , Eva, and goes to work carefree.

Louise's presentation to the investor group is a success, and the entire editorial team is relieved. Thomas is especially enthusiastic about her.

To Bruno's great frustration, it is not he but Louise who is appointed by Vic as successor to Louis. Thomas is happy with that, but Bruno makes it clear to Louise that he has a tough opponent.

The next morning pictures of Bruno in embarrassing positions hang. He realizes that Louise is responsible for that. Thomas is happy with the prank that Louise has played.

Thomas is more interested in Louise than in Natalie. Bruno wants to take revenge on Louise and tries to get Anouk to his side. He follows Thomas when he goes to Louise's house.

When she comes into her office, Bruno turns out to have organized a welcome party. Kaat deliberately spills coffee on Louise's clothes. Together with Anouk she guides Louise to the toilets to steal her clothes.

Vic has problems with his wife Claudia. In addition, the grandson of the woman he knocked over, Nico, demands a job in the company. The editors are busy looking for a suitable model for the cover.

Charlotte has received the radio address from an astrologer who may be able to help Louise. They visit the astrologer, but during their visit the man drops dead.

There are problems with the editors because Kaat's attitude makes the model for the cover of the song about witch women run away. Louise appears at work in a flashy outfit.

Louise helps Thomas find Femke. She saves the child from a colliding car. Afterwards Thomas makes photos of Louise that can be used for the cover about witches.

Jana suspects Nico of stealing her iPod. Vic is furious that Louise wanted to be on the cover of Don on her own initiative. Thomas takes all responsibility.

With Charlotte's help, Louise finds someone who can deliver her false papers so that Anouk can sort out her enrollment as an employee. Louise decides not to call the witches number.

Louise is heartly fired. Bruno enjoys the situation and rubs some salt in the wound. He suggests that Thomas deliberately set a trap Louise for.

The witches edition even gets attention on television. But on the editorial board, the vote remains below zero. Louise goes there to pick up her stuff and throws it all in the river.

Vic orders Bruno to find Louise and tell her that her resignation has been withdrawn. Louise refuses the offer first, but after seeing Thomas' video message, she agrees to come back.

Louise suspects Theo and Bruno are trying to arrange something behind her back. She does not trust the business and follows them to the sauna where they have agreed. But as a woman Louise does not get in.

Louise takes Annelore home. Anouk catches Bruno with another woman. Louise is about to go to bed with Annelore, but eventually turn off kissing another woman as a woman.

Louise explains to Thomas that she doesn't like women. But Thomas doesn't want Louise to contact his daughter yet. Charlotte also seems to no longer want to contact Louise.

Theo begins to worry about the soured relationship between Anouk and Bruno. Louise blames Thomas for getting kissed by the first woman.

Louise tries to glue the chunks to Thomas, but only makes it worse. Theo decorates Anouk, in order to get her cooperation for the profit that he and Bruno want to do with an advertisment.

Louise watches a football match at home, because she is not welcome with male colleagues. She flees into her world of fantasy. Charlotte is in a bad mood for a crooked date with Maarten.

Louise cramps when she wants to kiss Thomas and goes home frustrated. Anouk and Theo go to bed together in a hotel, while Bruno is biting his nails.

Vic wants to call Louis. Maarten comes to eat with Louise and Charlotte. Charlotte gets jealous when he pays too much attention to Louise.

At Charlotte's request, Elvis helps Louise's voice distort so she can make phone calls like Vic with Louis. Vic is over the moon when he finally makes contact with Louis.

The thief is wanted, and the money is discovered in the pockets of the company's doorman. He is promptly fired. Louise is pretty sure the doorman didn't do it.

Bruno and Anouk find a way to find out who Louise really is. They hope to find out more through her medical certificates. Louise refuses to go to a doctor as a woman ...

Louise in no way approves of the relationship between Charlotte and Maarten. She hates Maarten. And that is confirmed again during a dinner for which she asks Thomas to play her regular friend. T ..

A new experience as a woman awaits Louise when she discovers that not only men have her on their feet. Charlotte tries to persuade her to wax but it does not go as it planned ...

Bruno wants to phone Louis at all costs. Louise enlists the help of Charlotte and Elvis, but not everything goes according to plan. Bruno smells danger and confronts Charlotte with his suspicion ...

Natalie goes out of her way to win over Thomas. When Louise evades him, Thomas suspects her to be jealous. But she has another reason: Louise has her period for the first time ...