Jade, Jackie'nin haberi olmadan tavşan tılsımını okula götürmeye çalışır, ancak Jackie'den saklanırken 13. Bölüm'ün laboratuvarında tılsımın deneysel bir kronoton ışınına çarpmasına yanlışlıkla neden olur. Jade, okula geç kalmamak için tavşan tılsımını kullanmaya çalıştığında, zamanda geriye ışınlanır. Valmont, Jade'in yarattığı portaldan Karanlık El'in infazcılarını onu ve tılsımı bulmak için gönderir ve Jackie, özellikle geçmişteki hali ölümcül tehlikeye düştüğünde, onların peşinden koşmak zorunda kalır.

Jade, Shendu'yu yenip onu bir heykele hapsederek güçlerini içeren tılsımları dünyanın dört bir yanına dağıtan savaşçı Lo Pei'nin antik pişmiş toprak heykelini yanlışlıkla kırar. Hasarı onarmak için at tılsımını kullandıktan sonra, Jade, Lo Pei'nin kalan tılsımların yerlerini paylaşabilmesi için heykeli fare tılsımıyla yeniden canlandırmaya karar verir. Ancak Jade ve Jackie, özellikle Karanlık El'in onu tılsımları kendilerine teslim etmesi için kandırmaya çalışmasıyla birlikte, Lo Pei'yi düşman olmadıklarına ikna etmeye çalışırlar.

Jackie ve Jade, Güney Amerika'daki Culebra Gigante tapınağında saklı olduğunu öğrendikleri yılan tılsımını bulmak için yola çıkarlar. Ancak kısa süre sonra, kendi televizyon programında başrol oynayan bencil bir arkeolog olan Wesley Rank ile yolları kesişir. Rank, arkeolojik üstünlüğünü kanıtlamak için tılsımı kendisi bulmaya çalışır, ancak Karanlık El'in gelişi arayışı zorlaştırır. Jackie, tılsımı geri almaya çalışırken aynı zamanda Karanlık El, Rank ve tılsımın koruyucusuyla da uğraşmak zorunda kalır.

Tohru's mother comes to visit him and clashes with Uncle. Meanwhile, Tohru is almost seduced by a rival gang, the Black Hand to return to crime and help them steal the statue of the Golden Octopus.

The Dark Hand, with the power of the Talismans, goes on a crime spree. Although Jackie is eager to leave Section 13 behind, he agrees to help them one last time against the Dark Hand. Meanwhile, Shendu escapes back to the real world and tries to possess Jackie but accidentally possesses Valmont instead.

The Dark Hand goes hunting for the legendary Pan'ku Box which will lead them to the eight Demon Portals. Knowing that the Dark Hand is too strong with the Talismans for Jackie and Uncle to handle alone, Jade recruits El Toro Fuerte and Viper, along with the reformed Tohru, to form the J-Team.

Shendu and the Dark Hand find a clue to the first gate that will enable him to release his sister, the Mountain Demon. Jackie goes to Japan to stop them, while Uncle begins to train his new apprentice, Tohru. Meanwhile Jade causes havoc with a duplication spell.

While exploring some Pyramids in Mexico, Jackie gets a call from El Toro. He needs Jackie's help dealing with the legendary El Chupacabra.

The Dark Hand allows themselves to be captured and sentenced to prison so they can open the Wind Demon's portal in Hollowlands Prison. Jackie must go undercover.

Jackie guides a wealthy museum supporter on a expedition to find the remnants of the Muntabs. They discover the Muntabs aren't extinct.

Shendu goes to Hollywood to free his brother the Thunder Demon. Jade tries to make Jackie the next big action superstar in Hollywood as Jackie tries to prevent the demon from returning.

Jackie and company stop in ghost town. They find a book with the story of Jackie's ancestor who was a sheriff in the Old West.

When her classmates get a tattoo, Jade decides to get one also. The design she chooses, however, comes from a magical book, which has unexpected consequences.

Jackie is asked to authenticate some artwork in Paris. The art is stolen by Origami, a thief who can fold himself like paper. Jade calls Viper hoping the ex-thief can help them capture him.

The Dark Hand must travel into space to free Tso Lan, the Moon Demon. Jackie and Jade travel along as stowaways on their stolen shuttle and must hold off the demon so Tohru can arrive on the reserve shuttle with the Chi Spell ingredients. With Uncle handling the incantations from NASA Mission Control, they must seal the Demon Sorcerer back in the void before he uses his gravity-manipulating powers to change the face of Earth forever.

Jackie searches for the Lotus Temple. Jade gets lost and finds the temple. She also encounters a young girl who is cursed. Jade promises to help her break the curse.

Jackie is excavating some ancient armor when Uncle reveals it is the Armor of the Gods. This ancient suit of armor was worn by the Eight Immortals in their battles against the Demon Sorcerers. It proves quite convenient when the Dark Hand travels to Spain to find the portal of Dai Gui, the Earth Demon. However, sealing Dai Gui is complicated, as Jade used a sleeping potion on Uncle because of his constant complaining.

Section 13 sends its best Agent, Taggart McStone to stop Dr. Necrosis. Jade stows away and accompanies him on his mission, sending Jackie after them.

The Dark Hand seeks out the next Demon Portal at Fenway Park. Hsi Wu the Sky Demon, flies out of the Demon Netherworld but it's right in front of the girls bathroom door, and his tail snaps of as Jade tries to close the door. Hsi Wu disguises himself as one of Jade's classmates and they become friends. But once Hsi Wu learns that Uncle put a Chi Spell on his tail, an angered Jade uses some of the Talismans to confront him.

Jackie and Uncle are supposed to explore an underground city the same night as Jade's theatrical debut. Jade's upset that no one will be there to see her perform, and comes up with a solution. An ancient evil is freed from the underground city seeking revenge on the descendants of the one who imprisoned it.

Jackie discovers a necklace, known as the Eye of Aurora, that allows its user to teleport anywhere by saying "Return to (name of place)". To occupy Jade, he signs her up for Buttercup Scouts. However, an evil treasure hunter arrives looking for the necklace, which Jade has taken on a camping trip to Summit Hill with Jackie.

The museum asks Jackie to help someone who claims to have made a major discovery in the arctic circle.

An evil dentist smuggles an ancient artifact called the Holy Sutras in Jackie's filling. The hero must prevent the Sutras from falling into the wrong hands.

Jade befriends the boy king of Tangra when he comes to visit, and uses the Snake Talisman to get out for some much-needed fun. Unfortunately, this falls right into a plot to kidnap the young king and hold him for ransom.

The Dark Hand releases Bai Tza, the Water Demon. She seeks out her old kingdom – Atlantis, but when she finds it in ruins, she chooses to drown San Francisco as a new home with some information from Finn. Meanwhile, Valmont manages to render Shendu out cold and seeks help from the Chans to exorcise him from his body. However as Uncle is preoccupied with finding a spell to stop the flood, so the Chans with Valmont have to face Bai Tza without him.

Before Bai Tza can use another flood, Uncle uses a gourd from one of the Immortals to seal her away again. Unfortunately, Jade steps too close to the chi spell and is dragged into Bai Sa's portal. Meanwhile, the Demon Sorcerers communicate with and confront Shendu. In order to escape punishment, he promises that all seven of the Demons can use his own Portal – the only one left – to come back to Earth. A race against time ensues as the Chans work from both sides to both recover Jade and close the last portal for good.

Shendu alters the Book of Ages, and changes history. In a world where demons rule, Jade remembers how things were, and must convince her Uncles to help her set things right.

Jade, Uncle, and Jackie escape from Shendu's palace with a few talismans taken from Shendu. Using Jade's memories of the Immortal symbols, they embark on a mission to find the other members of the J-Team and manage to banish half of the Demons in the process. Realizing what has transpired, Shendu and the other three remaining Demons make a final stand at Australia to prevent history from being corrected.

Jackie finds a highly valued cat statue. Anyone who is scratched by it is magically transformed.

Jackie provides security for a valuable Chinese artifact. The museum decides to transport the artifact via a cruise ship, and allow Jackie to take his family along. Tohru's mother joins them on the cruise.