Becky and Stacy are sisters who were born with the birth defect of a cleft palate. After nearly 40 surgeries to correct the deformity, the sisters basically gave up and accepted that they would forever look the way they did; that is, until they placed their dreams to be normal in the skilled hands of the doctors of last resort: the Extreme Makeover team.

After years of torture from classmates, Tim , a 30-year-old assembler for Siemens Energy and father of two from Kenton, Ohio, wanted a new look to match his improved self-esteem. He gets an Extreme Makeover; not just a total body makeover, but a reverse vasectomy, to enable him to give his wife the baby she desperately wants.

On this episode, David, a musician, gets help attaining his dreams of stardom from Tom Keifer of the '80s band ""Cinderella""; experts help Amy, a woman who has severe acne, to regain her beauty and self-esteem.

On this episode of Extreme Makeover, Jeanene, a tattooed factory worker, is transformed from goth to glam, while Lina, a recent college graduate who looks older than she is, gets a new look.

Kristi, a 22-year-old violinist, has excess skin removed from under her chin; Heather, a 33-year-old nurse and aspiring actress, undergoes a hair transplant procedure.

First up, on this episode of Extreme Makeover, we meet Elisa, a successful 38-year-old sales and marketing director from Van Nuys, CA, whose appearance has caused her to be the brunt of ridicule and alienation since childhood-especially in high school. However, she has decided to take on her 20th high school reunion to erase her bad memories and has turned to the Extreme Team to take her to the top of the class. Elisa's procedures include endoscopic brow lift, upper blepharoplasty (upper eyelid lift), release crow's feet, rhinoplasty, liposuction on hips, thighs, knees and under chin, breast lift, tummy tuck, Thermage to arms and legs, V-beam to cheeks, schlerotherapy for leg veins, laser hair removal to face, legs and bikini area, LASIK eye surgery, a da Vinci porcelain bridge, 2 dental implants and Zoom whitening. Just imagine what her classmates will think!

Ethan and his wife, Geri, were married six years ago when they secretly eloped to Las Vegas. Geri's children from her previous marriage — Denae (20) Amber (18) and Josh (15) — never got to see the wedding. Now, this Clovis, California clan is treated to the first-ever, full-family Extreme Makeover in the show's history. The family is given a life-changing experience, as they are able to change their looks in an effort to transform their lives and destinies and to make their dreams come true.

Jason, aka ""Bubba,"" is a bartender and rodeo rider whose looks and body had been broken down from all his rough riding and honky tonk nights. He's a showman when he's riding the bull, but he hides when the bar's ugly lights come on at closing time.

Witness the all-new and exciting makeovers of Valerie, a 43-year-old housewife from Bland, MO and Mary, a 35-year-old third grade teacher from Southfield, MI.

On this episode, we see exciting makeovers of Bill, a 42-year-old Home Depot Expediter from Bastrop, TX and his sister, Kim, a 44-year-old court reporter from Round Rock, TX.

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In what is the most difficult challenge ""Extreme Makeover"" has ever faced, Aimee's case is rife with the most mind boggling obstacles to realize her dream of being beautiful. Selected form a Las Vegas casting call, Aimee dreams of living out the plot of her favorite movie, Pretty Woman, and ""to smile all the time, like Julia Roberts."" Dr. Brent Moelleken, the Beverly Hills plastic surgeon operating on Aimee, calls the surgery, ""the most difficult case in his entire professional career."" Indeed, the odds appear to not be on Aimee's side, and the ""Extreme Team"" wonders if this transformation can even be completed. However, this ""Pretty Woman"" hopeful fully dedicates herself and shines in spite of these obstacles.

Tricia and Kari are two exuberant best friends who have gotten into trouble and mischief together since they were 13 years old. Kindred free spirits and soul mates, they've been through a lifetime of fun, adventure and heartbreak. Two years ago Kari endured the loss of her six-year-old son, Hunter, who was born missing 90 percent of his brain. During the tragedy, Kari went through depression and gained a lot of weight. With the help of best friend Tricia, Kari was able to get through the hard time. Now these two frazzled ""Desperate Housewives"" will leave the car pools and housework behind and head to Los Angeles, where they are about to embark on the greatest adventure of their lives-an extreme makeover together. See how the ""Extreme Team"" helps this real life ""Thelma and Louise"" duo realize their dreams of becoming beautiful.

Lachele is a care worker for mentally disabled people from Cincinnati, OH, who dreams of one day becoming a nurse. She acts like a second mother to her siblings, a younger brother and sister, and wants to become a nurse to continue helping other people. But her looks prevents those around her from taking her seriously and seeing past her appearance. Marcelo is a pizza delivery man from Altadena, CA, who was forced to take care of his sister and grandmother when they were taken away from his parents. He has always dreamed of attending college to become a psychologist but lacked the self confidence to pursue his dreams. Marcelo is embarrassed about how he looks and feels ashamed of his acne when others call him ""Pepperoni Face."" But finally, a dream deferred becomes a dream come true, thanks to the confidence an Extreme Makeover creates. Now Lachele and Marcelo leave their homes and travel to the ""Makeover Mansion"" and get a chance to take care of themselves, after helping so many others

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The cleft palate that Jeff was born with was just one of his early hardships; his mother and her eight children had been left homeless, often sleeping under bridges in Miami. Despite this adversity, his mother got a job nursing and taught all the kids self-sufficiency, not self-pity, while saving money for Jeff's surgeries. Everyone in the family supported Jeff, as his cleft was their shared cleft. Jeff is reunited in Hollywood with his brother, Eddie, who acted as Jeff's surrogate father while growing up. Jeff's surgery was deemed by Dr. Griffin and Dr. Dorfman as one of the most challenging cases of their professional careers and, in the most amazing and emotional reveal of the season, an entire family's burden is lifted and their pain healed. A reclusive homemaker and wife/mother of three kids, Angela has preferred to stay at home rather than socialize because of her looks. All her life she endured constant torment due to her 'cartoon character' appearance. She would like to stop hi

Nathaniel was the first person to graduate from college in his family, but has been rejected for decent jobs because of his appearance and terrible looking teeth. As a former psychology major, he's frustrated that he's been unable to fully utilize his intelligence, working instead on assembly lines and at gas stations. An avid stock car racing fan, he fantasizes of being a winner -- especially at the Indy 500. But his ultimate dream is to get married and have a family. Nathaniel is about to take the ride of his life when the ""Extreme Team"" perform some major body work before sending him across the finish line as a winner. Indy 500 star Dan Wheldon introduces Nathaniel's new look and offers a sweet surprise at his reveal at the Indy 500 Hall of Fame museum in Indianapolis.

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