The dogs arrive at the Grand Canyon, who try to solve a puzzle. Upon completing the puzzle, Little Dog quips that the word 'jerk' should've been part of the answer to the puzzle. His voice echoes across the canyon, and misconstrue the echo as another dog insulting them.
The dogs come across a tennis club, where they see tennis balls being served back and forth. Little Dog wants to join them in order to chew them, but gets overwhelmed by the number of tennis balls lying around.
The dogs wander onto a line for the post office. Oblivious to the purpose of a post office, the dogs spend all day waiting in line, attacking mail carriers and even enlist for the army via Selective Service System.
The dogs find a package delivery of ice cream-related products before them when they both wake up. Little Dog suspects as too good to be true and that they must be still asleep so the two try to wake themselves up.
Big Dog falls in love with a hamster displayed in the window of a pet shop, so he and Little Dog search the store for the hamster. Chaos ensues when they find that Mr. Hollywood owns the store.
The dogs see a gigantic bone being shipped to a museum, and decide to wait for it to come back outside. They wait so still, the movers suspect they are part of another exhibit and take them into the museum too.
In a last ditch effort for some food, the dogs climb a 3D billboard advertisement shaped like a giant bowl of soup. When the find that the bowl is "dry", Big Dog fills the bowl with his spit. He soon dries out, so Little Dog must find a way to rehydrate him.
When the dogs find that a new diner nearby them opens up tomorrow, they attempt to do fun activities to pass the time before restaurant opens.
The dogs confront a bum in front of the White House. A fight ensues between them, which results in the foreign ambassador and Big Dog switching occupations. Big Dog goes off to attend a political party at the White House, and Little Dog (who mistakes the ambassador for Big Dog) tries to get his friend out from his "amnesia."
The dogs wish for some "Fudgie Scout Cookies" but struggle to go after some until they come to the conclusion that they need a door.
The dogs enlist in a boot camp that trains cartoon characters to become hardcore animation icons.
Big Dog awakes in the middle of the night wanting to relieve himself. Just as he finds a spot, Little Dog stops him, making a point that this is their home, so they need to find a more suitable place. They end up inside an indoor bathroom, where hilarity ensues as Little Dog has to groom Big Dog up to go like a human.
Big Dog and Little Dog infuse their type of humour into a parody of a silent black-and-white cartoon, in which they must save a young girl from a villainous feline villain.
