Gonzo is finally ready to settle down and get married, and his friends are planning a big bachelor party. Everything seems to be perfect, until the husband of the bride-to-be appears on the scene.
A couple desperate for a child adopts a black-market baby, only to discover that the infant is addicted to heroin and has a heart condition. Stanley recruits Trapper and Gonzo to join him in a relay race against Bay General.
Gloria's Brother Brian flies in from Texas for a visit. He manages to turn Gloria's Life upside down. As a result of his drinking problem, her work at the Hospital suffers and she is given an official warning. Meanwhile a patient is trying to set Trapper up with her Daughter.
Stanley wants to upgrade the hospital's image, and puts forth a talented staff surgeon as a ""typical"" SFM doctor - until he learns that the man is a local Ku Klux Klan leader.
The leader of a pop-psychology programme becomes a patient at the hospital, resulting in threats against his and Gonzo's lives.
San Francisco Memorial Hospital is endeavouring to put into place a co-operative care programme. Due to Arnold Slocomb and the Board of Directors, budget cuts. Mrs Fitch and her Neice, Liza are the perfect candidates. If Mrs Fitch would only accept Liza's help.
A woman prisoner gives birth to a premature baby, who is rushed to SFM for care. The mother, upset at not being allowed to be with her child, beats the prison warden who refused to arrange for her to be taken to the hospital.
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A street-corner Santa Claus worries more about a sick boy than his own ill health.
A respected cardiologist is so fearful of what he believes to be psychic visions that he has become unable to function at home or at work.
A young man admitted to the hospital following an accident informs the staff that his name is ""42"", and he is an alien just visiting earth. While building a transmitter to contact his home planet, 42 befriends a sick and lonely lady.
Trapper buys himself a gun after being robbed, then has second thoughts.
Someone is killing terminally ill patients at San Francisco Memorial, and it appears to be an inside job. A young woman with chronic pain is learning how to deal with it, but maybe not soon enough.
A mentally disabled man who works at the hospital is able to make friends with a crotchety old hermit who is dying of cancer, but gets embarrassed and quits his job when he misinterprets Gloria's feelings for him.
A woman who devotes her life to getting teenaged hookers off the street is badly beaten by a pimp. Gonzo's disgust at their apparent disinterest convinces the girls to get revenge on the attacker, while having two prostitutes show up at his house seriously hampers Trapper's love life.
The mother of a 16-year-old boy with a gland disorder preventshim from having hormone injections that would cure his problem.
A doctor that comes to SFM with an accident patient is so good that Slocum wants to bring him on staff, but he runs into a problem - the schools the man claims to have trained at have never heard of him. Jackpot is frustrated by a Jane Doe with a high fever and some unusual symptoms.
A former lover names Gonzo in a paternity suit after learning she has a serious cardiac condition.
Ernie is engaged to be married, but begins to have second thoughts when her fiancé expects her to take all of the responsibility for the house, his five children and their relationship while he relaxes after work and serves as nothing more than a playmate to his out-of-control kids.
A 74-year-old woman who is admitted with a blocked artery in her leg has another problem - she is hooked on prescription medications. When Trapper and Gonzo discover that her doctor is responsible, and treats all his patients the same way, they plot to drive him out of business.
Jackpot is put in charge of Emergency Services while Trapper, Gonzo and Stanley attend a medical conference in Mexico. South of the border, Trapper falls in love with another doctor, but they may have too much in common for the romance to last.
Jackpot convinces several of the staff to invest in a promising young boxer he is managing, but after the fighter kills his opponent in his first professional match he begins to suffer mysterious injuries that may keep him out of the ring permanently.
A rumour that Trapper may be leaving SFM for a hospital in Boston has several other staff considering new positions. After 72 hours on duty and the loss of a patient, Stanley is displaying psychotic symptoms, and ends up in jail.
A man who needs a bone marrow transplant to survive claims that he has no relatives that can serve as donors. However, Gonzo soon discovers that the truth is a little more complicated: the man is in the Witness Protection Program, and cannot safely have contact with his family.
A flower salesgirl, who works on the street, wakes up one day at the hospital. The girl is very ill yet refuses to be treated since she considers that doctors are Satan's henchmen. The estranged mother of a cult member has the girl kidnapped from the hospital.