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1. Bölüm Suddenly finding himself in the Edo period, neurosurgeon Jin Minakata tries to return to the present day. But an oddly familiar stranger intervenes.
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2. Bölüm As Jin struggles to process the startling reality of his situation, a resurgence of a mysterious illness frightens residents across the city of Edo.
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3. Bölüm Just as Jin learns the shogunate will support his efforts to treat cholera patients with new techniques, he suddenly shows signs of infection.
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4. Bölüm Jin meets a courtesan with a striking resemblance to his fiancée in present-day Tokyo. She asks him to perform a life-saving operation on her father.
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5. Bölüm Jin takes on the ambitious task of producing penicillin to help Nokaze’s sister, a patient suffering terribly during the final stage of syphilis.
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6. Bölüm While visiting an eminent doctor of traditional medicine, Jin is pressed about his medical background — and soon gets an opportunity to prove himself.
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7. Bölüm When Jin learns of a patient with a terrible burn, he wants to help her. But the treatment requires a skin graft and a large amount of penicillin.
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8. Bölüm Nokaze asks Jin to treat a sick courtesan, but he needs stronger penicillin to cure her. Kyotaro gets an idea to secure the funds required to make it.
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9. Bölüm With both Nokaze and Saki developing strong romantic feelings for Jin, bells ring out across Edo warning of a dangerous fire engulfing the city.
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10. Bölüm When Jin visits Yoshiwara to examine Nokaze before her impending marriage, he notices something concerning during the exam but chooses to stay silent.
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11. Bölüm Jin wonders whether Ryoma might have traveled into the future during their tumble from the cliff. Saburi and Jin reexamine Nokaze’s symptoms together.