Jac, Ric and Sacha face off against old rivals while pitching for a million-pound prize fund. But as the competition threatens to divide the group, should they be more worried about their friends than their enemies?

A surprise blast from the distant past returns to run a Young Adult Unit alongside top consultant Ange Godard. He successfully puts everyone on tenterhooks with his notorious barbs and quips, until things take a surprising turn, much to everyone's surprise.

Ange finally allows Dominic the chance to work on her new unit, after much persistence, but she isn't sure whether he has the chops to be a great doctor. When Dominic is economical with the truth, Ange has to confront him and then feels that he's not trustworthy.

Frieda is happy her life is on an even keel, but her contentment is shattered when her ex-boyfriend Roman unexpectedly reappears. Can a wary Frieda open her heart and dare to imagine a future she had thought was gone for good?

When Holby is overwhelmed by a winter crisis, Ric goes above and beyond to treat his patients. But as the pressure reaches fever pitch, can he continue to accept Holby surviving on nothing more than good will and the occasional miracle?

When a family secret is exposed, the dispute causes a young patient to delay vital surgery, but fearing the consequences of such a decision, a concerned Ange must find a way to make her reconsider.

While Holly's condition weighs heavily on an emotionally invested Ange, Holly's distraught parents must put their differences aside to make a heartbreaking decision, but are they prepared for what lies ahead?

Zosia arrives at Holby keen to get back working on Darwin. With her knack for irritating Jac in full swing, will Jac be able to track down Frieda before Zosia gets too comfortable?

Zosia's big news gets a mixed response, and Jac remains suspicious about her real reasons for returning to Holby. Zosia's situation is further complicated when a handsome American turns up wanting to tempt her back across the Atlantic.

A computer virus shuts down Holby’s power, putting Jac and Connie at loggerheads as they fight against all odds and in makeshift conditions to save the lives of close friends and colleagues.

A desperate Ange pleads with Holly’s family to see reason, but when the ruling comes back, the anger finally boils over with devastating consequences for Fletch. Ric's son Kofi arrives at Holby wanting to find out what’s going on with Darla. Struggling to keep his granddaughter's pregnancy a secret, Ric battles to keep his family together and do what’s right for everyone. An excited Zosia looks forward to working with Frieda, only she doesn’t get the reception she was expecting. As the pair team up to tackle a case, Zosia does her best to win over Frieda, with hilarious results.

As the protesters grow angrier Holby tightens security, Fletch realises there may be darker forces at play with Theo’s disappearance. Chloe struggles to decide if staying at Holby is the right thing to do. Dom tries to persuade her, but is thrown off by a surprise visitor. A romantic evening doesn’t go as planned for Xavier and Donna when his mother arrives, putting Donna in a difficult position.

Ange follows a hunch and ends up uncovering a shocking and long buried secret – one with the potential to tear her life completely apart.

Chloe is surprised and immediately wrongfooted when ex-boyfriend Evan unexpectedly turns up on Darwin Ward. Is it possible he’s simply there to care for his sister Phoebe?

A bewildered Dom struggles to come to terms with a shocking family secret and he immerses himself in work. However being around Ange

A startling incident forces Zosia to reconsider her future at Holby, Cameron has to treat a close relative of Xavier's, and Dom tries to keep Carole at arm's length.

Jac’s top-dog status is challenged when a talented new surgeon starts at Holby and instantly causes a stir. Dom is irritated when Carole starts work on reception, and Ange tries to limit family fallout. Donna is flattered to be offered a new career opportunity, but does she really want the extra responsibility?

Kian’s big personality and alternative methods are beginning to grate on Jac, but is it just a case of professional jealousy? Fletch reminds her that she’s only as good as her team and should allow him to thrive. Dom tells Ange he wants to be a proper part of her and Chloe’s lives. In response Ange finally opens up to Dom, revealing a big family secret. When Sue makes a big mistake on her first day at the new job, Donna covers it up. However being the favourite of the new boss poses new challenges.

Ange plans to tell Chloe her biggest secret, but a surprise locum throws her day into disarray. Ric’s granddaughter, Darla, arrives at Holby, forcing Ric to deal with her pregnancy head on. Kian rallies Nicky and Cameron to help him find out who Jac’s mystery patient is.

As Chloe tries to come to terms with the news that Dominic is her half-brother, she’s forced to operate with him and Ange. But as tension boils over and Evan helps her uncover a home truth, will Chloe be able to cope?

Dominic faces his difficult past when he goes head to head with his abusive ex, Isaac. Ange and Carole band together in order to cope with the fact that Isaac has returned, affecting Dominic’s life. Jac’s conscience is thrown into conflict when she meets a previous patient who has something she wants. How far will she go for personal gain?

Will Lofty and Dom’s marriage survive under the pressure of Isaac’s presence at Holby, and is Sacha’s relationship with Patricia over before it’s even begun?

As Dom and Isaac grow closer, is Dom at risk of falling under his spell? Hanssen finds himself in unfamiliar territory when an estranged relative arrives at Holby, and Chloe gets an unpleasant surprise when she returns to work.

The manipulative Isaac continues to drive a wedge between Dom and Lofty, but when Isaac puts Lofty in harm’s way and the net is closing in, is Isaac’s fate sealed?

When Xavier’s mum arrives on AAU talking in riddles, Donna does her best to shelter him from her behaviour - but will he appreciate the intervention? Sacha makes a romantic gesture but finds something unexpected in Patricia’s cleaning cupboard. Nicky turns her nose up at working with Jac, who ensures she’ll live to regret it.

Xavier tries to build bridges with Donna, but she’s having none of it. Cameron can’t quite shift his feelings of unease around Evan, and when he overhears a phone call his suspicions are confirmed. And Fletch is anxious about his first official date with Ange, especially when work threatens to get in the way.

Cameron tries to prove himself to Kian, but they clash over Kian's teaching methods. A frustrated Xavier gets relationship advice from the most unlikely source, and Carole opens up to Hanssen about her woes with Dominic and impending divorce.

Chloe’s day is thrown into chaos when Evan is attacked. With his life on the line, Evan asks Chloe a surprising question. Dominic is put under pressure when a surprise visitor arrives at Holby looking for Lofty. Wanting to keep his marriage intact, Dominic is forced to make a difficult decision. And after a night of partying together, Serena and Fleur Fanshawe are thrown together to help a patient on AAU.

As her loved ones continue to worry about her, Chloe learns more about Evan. Cameron wants to get out from under Bernie’s shadow, but he receives some devastating news. Hanssen learns that his grandson is not the only one who believes in the tooth fairy.

On the anniversary of a personal tragedy, Kian decides he must save a life today. Hanssen worries that with his family history he shouldn’t look after Oskar and wonders whether nature or nurture will have a greater effect on his grandson. Cameron struggles to accept some recent news and refuses help from Alex. When Serena tries to help him, she receives surprising news.