After being locked out of her new house all night, Dr. Caroline Todd is forced to turn up to her new job at the local hospital tired and smelling like a mini-cab after using car freshener as a replacement for deodorant. She soon meets the strange staff, but anaesthetist Dr. Guy Secretan is very welcoming and offers her his spare room for the night while he works a night shift. However after a blocked toilet incident, she soon realises Guy's true motives after he turns up home early and she discovers there isn't actually a spare room.

While Joanna is extra careful to make sure that her and Statham aren't seen arriving together, Caroline isn't quite so lucky when she is spotted turning up with Guy after having spent that night at his place. Despite Caroline assuring everyone nothing happened between them, Guy is happier to play up to the rumours spreading around the hospital until Caroline forces him to admit the truth by digging up some dirt to blackmail him with.

Worried about her age Joanna is also concerned about the dreariness of her relationship with Statham, who in turn tries to spice up their relationship through spontaneity (with the help of playing his recorder to get himself sexually aroused). However he soon becomes concerned that I.T. wiz and women-pleaser Lyndon Jones is trying to steal Joanna away from him.

Joanna is turning 42, but her day brightens up when she mistakenly thinks she has received a locket as a birthday gift from Lyndon, when it is in fact from the ever doting Dr. Alan Statham (filled with his own "love juice").

Hormones are abound in the hospital with Mac the centre of both Caroline and Sue's affections, Boyce and Kim having fun together and Karen writing a love poem about Martin who in turn is desperate to impress Caroline. And of course there is Joanna (sporting a new bleached hairdo) who is still after Lyndon much to Statham's annoyance, and so after listening to Boyce's advice on women, decides to act mysterious by playing 'kidnapper' and having his way with Joanna in the woods.

Hungover and worse for wear, Caroline is feeling the effects of the party the night before, which she still can't completely remember. When her kissing exploits come back to her, she is forced to trawl the hospital to apologise to everyone she kissed and insist it meant nothing – even to Mac, who of course it meant everything with.

Statham still isn't completely over Joanna and spends all his day trying to win her back by pretending to hang himself, singing ‘All By Myself' to her via a megaphone and by challenging Lyndon to a tug-of-war in the cafeteria for the hand of Joanna. However when he meets the hospital's chaplain Cordelia he soon finds another object for his affection.

The hospital is hosting a charity Grand Slave Auction with Statham, Caroline, Guy and Lyndon all up for bid and while there is high competition for some, others aren't so lucky.

It's Mac's last day and Sue and Caroline are struggling to cope with the thought of losing him. While Sue offers to kill in order to keep Mac in the hospital, Caroline spends most of the day trying to find fault with Sheffield in order to deter him from leaving.