Lise Birinci sınıf öğrencisi Isagi Yoichi, kale önündeki arkadaşına pas verdiği için Milli Takım şansını kaybeder. İşte o zaman Blue Lock için bir davetiye alır. Blue lock Japonya'nın Dünya Kupasını kazanabilmesi için lise çağındaki 300 forvet arasından dünyanın en iyi forvetini yetiştirecek bir tesistir.

Kira, Blue Lock'tan elenir ve bununla birlikte Isagi Yoichi'nin hayatında dünyanın en büyük santrforunu yaratmayı vaat eden Blue Lock'taki ilk gün başlar

İlk seçim, Bina Beş'te V, W, X, Y ve Z'den oluşan beş takımın turnuvasıdır ve sadece ilk iki takım ilerlemeye hak kazanır. En alt sıradaki takım olan Isagi'nin Z Takımı, X Takımına karşı oynar. Ancak takımın en skorer oyuncusunun bir sonraki bölüme geçmesine izin veren özel kural nedeniyle maç, takımlardan bağımsız olarak kaotik bir mücadeleye dönüşür. Oyunun kaderini değiştiren ise X Takımının forveti Barou Shoei olur

Team Z was crushed by Team X, who centered the offensive play around egoistical yet skilled Barou. Responding to Ego's urge to "take up a weapon," the players discuss what their weapons are in preparation for the next match. However, Isagi struggles to identify what it is. Using "the smell of the goal" he felt in the game against Team X as a hint, Isagi and the others go against Team Y in the next match.

Isagi relies on "the smell of the goal," his raw instincts, to make a move, and it leads to the fierce battle of "reading" each other's hand with Team Y's playmaker, Niko Ikki. Isagi and Niko's battle as they both watch over the whole field and throw their ego at each other, brings them to the last one minute of the match. Can Isagi and Team Z beat Niko's final strategy, "One Time Kill Counter"?

After the match with Team Y, Isagi's rank moved up, and he became the center of the team. The next match is against Team W, led by the Wanima twins. Their eye contact and impeccable combinations are hard to beat. They used to play in the same team as Chigiri Hyoma, and they use his past trauma to egg him on. Chigiri says that he joined Blue Lock to find a reason to quit soccer. Team Z leads the game with Kuon's play. Everyone's elated for the good start of the match, but Isagi feels something is off.

Because of Kuon’s betrayal, Team Z is faced with a desperate situation of playing 12-on-10, with the opponent knowing everything about their weapons and strategies. Even under such a circumstance, Team Z never gives up on the fight, and Isagi continues to believe in himself. Inspired by their passion, Chigiri runs through the field at an incredible speed, his weapon he has sealed away. His ego rocks the match when they are losing at 3-4.

The Z team has only one game left to play, and it will decide the future of its members. While everyone seems to be nervous about the kickoff, Isagi is trying to find a way to score goals without anyone's help.

The match continues to leave Team Z scared of Nagi's abilities. However, one of the members is not scared, even though they are facing a soccer genius...?

Each player unleashed their weapon and ego, and Team Z has caught up to a draw. They totally have the momentum of the game, but that has “awakened” Team V’s monster, Nagi. In the chain reaction to awakening, Isagi also learns to use his weapon and keeps fighting. The “heat” generated by the clashing of ego from both teams starts to affect Kuon as well.

Team Z launches a final counter to try and win against Team V. Isagi is trying to find the last piece he needs to crack the formula to become a goal machine.

With many dropouts, the "Blue Lock" project enters the second selection. A harsh second selection where former friends become rivals and former enemies become allies at a dizzying pace. There, Isagi meets Rin, the most powerful egoist ever, the younger brother of the genius Itoshi Sae, and the new Blue Lock ranking TOP ranker. Seeking further evolution, Isagi's fight advances to a new stage.

In this new stage of the second selection, the white team formed by Isagi, Nagi and Bachira will finally go against the top three in the ranking of the previous stage, running the risk of losing one of their three players if they lose the game. Still, the willingness to test their new skills against the top three is much stronger in the white team members.

The loss of Bachira on his team makes Isagi very anxious about what his future with Nagi will be like. To make matters worse, the situation is now even more complex: the ideal would be to go against a weaker team, but that would mean taking a weaker player too, which would make it more difficult to advance the next stages. So what are Isagi and Nagi going to do?

Isagi realizes that the conclusion of the match is in his and Naruhaya's hands. However, how will he go about beating Naruhaya? This will be a game that will not depend on genius players, but on "mediocre" players.

Barou joins Isagi and Nagi's team, already causing quite a stir with his conflicts with Nagi. Isagi is trying to see a way to mediate these two, which will be very complicated.

Isagi begins to realize that his former teammates made a great trio with Reo, making the best use of their own weapons. Now, he'll have to think about how he's going to get his much-desired "chemical reaction" with Nagi and Barou, if not, he won't be able to win. That said, the Barou remain not very cooperative...

By understanding and enhancing each other’s weapons, Isagi and Nagi are drawing countless paths to the goal. In contrast, with Chigiri, who has further evolved, at the center, Kunigami and Reo find themselves struggling to keep up, and a back-and-forth battle unfolds on the field. Meanwhile, Barou, who should have been the king of the field, was left behind in the evolutionary chain because of his overpowering ego. Having been robbed of the leading role on the field by Isagi, Barou finally falls to his knees.

Isagi and his friends barely manage to win as Barou awakens as the "villain" of the field. In order to cause a further "chemical reaction", they take away the only player who showed their ego to "eat" themselves and advance to the force stage. On the other hand, Bachira, who is looking for an opponent for the next match with TOP3, sees through the existence of a "Monster" in himself during training with Rin, and faces his own "ego".

Finally, Isagi and Nagi are going to have a rematch with Rin's team. However, adding Bachira to Rin's team will bring some unforeseen circumstances.

Isagi captures everything that’s happening in the field to see its future, and Nagi controls the space. Their combination bursts, and their series of play lights up the fire in Rin. Rin’s dominating play that encompasses everything on the field, from the skills of all players, the ball, positioning and tactics gradually corners Isagi’s team once again. As chaos and ego clash, one man is covertly sharpening his fangs to devour the game dominated by Rin.

The thrill of finally finding the "monsters" with overwhelming talent became short-lived, as Bachira realizes he's being left behind in the battle between Isagi and Rin. Meanwhile, the game is reaching its final stage, with a fierce back-and-forth battle led by the wild card, Barou. As Isagi takes his skills to the next level under extreme conditions, Bachira is forced to confront his own "ego" amidst the intensity of the situation. Where will their newfound powers take them, and what impact will it have on the game's outcome?

Bachira sheds his ideal of the "monster" and finally awakens his own ego. Until now, Bachira had been seeking someone to follow, but now he charges forward towards his own goal, finding in Isagi a companion who trusts in his ego. Isagi performs a decisive cut, but the ball made its merciless way to the victor's side... The time for the ultimate showdown has arrived, making sparks fly as the eight egoists clash. Which team will emerge victorious in the second selection's "Rivalry Battle"?

Rin chooses to add Isagi to his team, and together with Bachira they pass the second selection. Waiting for them on the other side is a 5-on-5 match against a team of world-class players. Thanks to Isagi, Bachira, and Rin's coordinated play, they manage to score the first goal, but they soon find themselves overwhelmed by the opposing team's superior skill and ability. Despite this, they desperately keep fighting until the last second, unleashing their own "egos." As a result, the "Blue Lock" project, aiming to produce the world's greatest striker, enters a new phase.

35 forwards remain after the 2nd selection at Blue Lock. With a big match against Japan's U-20s in three weeks, Ego announces that the team will be centered around the top 6 players. The tryouts for the rest of the positions begin.

Isagi is chosen as Team A1 along with Nanase and Hiori to play against Team B1, which includes Karasu, Otoya, and Chigiri. While Isagi struggles to find a way into the game, Chigiri and Hiori demonstrate their worth.

Seeing how incompatible Rin and Shidou are, Isagi hopes to take advantage of it. However, his physical abilities are not enough to get him where he needs to be. Then, Hiori suggests that Isagi does the thinking "on reflex."

Isagi looks back and analyzes what he did when he scored a goal on reflex. Then, when the second match begins, Reo finds his new playstyle: Chameleon.

The tryouts are complete, and Isagi is chosen for the starting lineup. But Shidou is nowhere to be seen... It turns out Sae has picked him to join the U-20s. Meanwhile, Ego begins the final training camp, where he discusses the secret of "flow."

The exhibition match between Blue Lock and Japan's U-20s has finally kicked off. The first play Bachira and Isagi set up has been swiftly shut down by the U-20s' captain, Aiku, and Isagi finds a new challenge in him.