While the Emergency Department continues to struggle with the casualties of the chemical explosion, Nelson exacts revenge on Colin.

As the team uncovers the horrible truth behind a young boy's alien fixation. Dan is glued to the phone desperately trying to help a man who has shot his wife.

Cate's Tae Kwon Do instructor arrives at ASED combative and battered.

Tempers fray as Vincent is frustrated by Jack's negligence and Nelson cracks under Frank's watchful eye.

A Work Cover claim has Charlotte and Nelson's replacement, Deanna, at loggerheads when an investigator for the insurance company insists their patient is a fraud. A middle aged man presents with stomach pain that is difficult to diagnose. No one can quite believe the cause when it is eventually located. Deeply concerned about Nelson's frame of mind since he quit his job in the Emergency Department in the middle of his shift, both Frank and Von decide to pay their former co-worker visits. But it's safe to say that Frank and Von receive anything-but-friendly receptions from Nelson, who is still outraged that his colleagues wrongly assumed he had begun drinking again. Deanna shows a side to her that Jack has not seen before.

A chaotic shift in the ED is complicated by the arrival of two Organisation and Methods officers sent by Alison Newell to evaluate the department. Tensions skyrocket in Resus when the staff is faced with an unusual resuscitation of a patient who appears to be slipping in and out of consciousness as CPR is being performed. The disturbing sight upsets Dan who walks out in the middle of the procedure. It seemed to be just another day on the job for Von, who is still trying to come to terms with the murder of her niece, Kerry. Nursing an insulin-dependent diabetic, Bob Tyrell, who has a leg wound, Von helps him the best she can. But things take a dramatic turn for the nurse and before the day's end, Von's future hangs in the balance when she finds herself before Dr Newell and the hospital board accused of negligence. Charlotte fights Admin to find a bed for a patient.

While the Emergency Department welcomes it's new doctor, Registrar of Emergency Medicine Sean Everleigh, Dan is thrown to find a young woman he recognises from his past denies knowing him when she is brought into the ward suffering from nasty leg and stomach injuries sustained in an accident on a railway platform. Frank becomes suspicious of Deanna's motives as the end of her stint as Nursing Unit Manager approaches. Nelson's last case to gain his Practitioner's accreditation proves to be a trying one when an old adversary brings his wife into the ED for treatment.

Frank is caught in the crossfire when a critically injured Jehovah's Witness requires blood transfusions to survive. A former TV personality, and hero of Dan's, is brought in and it soon becomes apparent that all is not what it seems with her home life. Deanna lodges a sexual harassment complaint against Frank.

Eighteen-year-old Jacinta Cosgrove is brought in after a terrible MVA and the battle to save such a young life is stressful for everyone. But it is even more heartbreaking dealing with her distraught father, Ian.

Deanna makes a dramatic departure from the Emergency Department and it's not a moment too soon, as far as her staff are concerned.

Frank pays a surprise visit to the Emergency Department and takes a back seat when the Medical Response Unit is called to attend to an accident in a commercial kitchen where a man's hand is caught in a mincer.

As one case of apparent rage and domestic violence leads to a fascinating neurological mystery, a second, equally confronting situation involving anger provides a sobering counterpoint. Vincent departs for Canada on a four-month surgical exchange program.

Jack arrives at All Saints clad only in jeans and a singlet after having awoken to discover his duplex burning down and a woman collapsed in the neighboring house's shower.

New intern Bartholomew West has a nightmare first shift in the ED. Between irritating Frank by his mere presence, saying the wrong thing at the wrong time, and stumbling through his assignments, Bart finds reason to question his ability but an encouraging word goes a long way to ease his mind. A pair of perplexing patients resulting from a fight at a house party give the staff cause for concern when their symptoms don't coincide with the doctors' expectations for their respective injuries. Frank is stunned when Nelson turns up on his doorstep in the middle of the night, looking far from himself. Dazed and with nasty wounds on his bare feet, Nelson is clearly in a bad way. What's more, by night's end he will have made a heartbreaking decision. But it's a decision he knows he has to make-and one that Frank helps him to carry out. Nelson, who is still failing to cope with the horrific murder of his bride-to-be, Kerry, pleads with Frank to admit him to a psychiatric ward.

All Saints new Head of Surgery, Mike Vlasek, has Jack Quade in his sights. Sean and Cate find there's something fishy about a little girl's illness. Bart bumbles his way to a brilliant solution although not without consequences, and he finally makes a breakthru with Frank who agrees to be his mentor. Frank is infuriated by the arrogance of Mike Vlasek, the new Head of Surgery. Alison has a shocking announcement for Frank: she's taking leave to go overseas, taking Kathleen with her. Dan reluctantly steps forward to become the Acting NUM.

Sean and Cate go out with the Medical Response Unit to save a young man whose head has been skewered by a metal spike in an accident at a medieval festival.

A couple on their way to the airport to begin an overseas holiday end up in the ED after an MVA. Ignoring medical advise, they are desperate to get on their way as soon as possible.

After a drunken poker night, Dan and Sean find themselves at loggerheads with a young man who shows signs of organ rejection.

When the life of a young boy is put in danger, Frank and Mike struggle to talk sense into the boy's father who is willing to do anything. Sean has to face his demons when assisting in a confronting operation.

Sean and Erica are put under enormous emotional strain as they try to help a twenty-two year-old patient cope with the fact that she may never walk again - and that her boyfriend may not be there to help her.

Mike attends his first MVA as part of the MRU and impresses all by trying everything to sustain the life of a young driver. Charlotte and Erica clash over how to best handle a seventeen-year-old sexual assault victim. Gabrielle continues to look out for new ways to maximise the potential of her staff.

Three patients come to the emergency department, all with similar symptoms; Frank's old university friend is admitted; Bart returns looking for a job; Eve plans a trip to Europe; and Von is made the transitional-care nurse.

Mike, Cate and, later Jack, find their 15 minutes of fame - much to Frank's fury and disgust - when they battle to save the life of a badly injured reality show contestant live on air. Dan learns not to judge his patients by their looks, no matter how intimidating or extreme, treat a young man with a jaw dropping facial piercing.

After a man who has been shot is dumped in the hospital grounds, he needs surgery to save his life.

When attempts to resuscitate a car accident victim fail, the team begin to suspect that all is not what it seems. Cate reveals Mike's terrible secret to Frank. Frank confronts Mike who denies everything.

The team are baffled by a woman with many faces who confounds the staff with her varied behaviour. Spence returns but not everyone is pleased to see him. Sean and Von track down the cause of an elderly couple's illness. In light of his sudden resignation, Frank challenges Mike to stay and face his demons.

Dan and Zoe deal with a patient who harbours a secret that leads to further confusion on an already complex diagnosis.

Jack finds himself at odds with the new trauma surgeon at the site of a gruesome motor vehicle accident. A man presents with a voracious rash and the team are horrified when they discover its cause. Von finds a teenager's emotional pain far worse than her physical injuries.

Spence's thoughts are with Charlotte as he treats a woman who looks to be miscarrying. Jack is rocked by a scandalous revelation about Bianca, while a former nurse creates bedlam in the emergency department.

A young boy with severe muscular dystrophy arrives at the hospital following a drug overdose. When he wakes and proclaims that he was supposed to have died, the hospital staff must decide where they stand.