650-lb Melissa begins her seven-year weight loss journey.

650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a childcare facility?