The team from The Suite Life of Zack and Cody sets sail in this new spin-off series. Zack, Cody, London, and Mr. Moseby move from the well-appointed lounges of the luxurious Tipton Hotel to London’s father's luxury cruise ship, the SS Tipton. At first, London thinks she is on a cruise vacation, but she soon learns that she has enrolled in Seven Seas High alongside Zack, Cody, and new characters Bailey and Woody. London’s father believes that while at sea, she won’t be able to skip classes, so she has to study. Moseby, along with MISS Emma Tutweiller, tries to ensure that the students focus on their studies, but Cody and Zack discover new ways to be mischievous.