Dr. Tenma, Director General of the Science Ministry, loses his son Tobio in an accident. He decides to create the robot Astro Boy, who looks just like Tobio, using the best of the Science Ministry's technology.

It is the year 2000 and robots have been put in charge of making other robots when there are no longer enough people to do the work. Astro Boy dreams of having a real mother, just like human boys. The robot workers are making an experimental new robot named Colosso who goes berserk and escapes shortly after coming to life. The only hope is for Astro Boy to stop him before he cause too much trouble. (In the original Japanese version, Colosso was named "Frankenstein")

Astroboy is selected to lead a search party to find the survivors of the first manned expedition to Mars. This meets strong objection from the spaceship's captain, who protests taking orders from a robot.

Professor Nutty Fruitcake grows giant fruits and vegetables. One day he breeds giant snails thinking they would be harmless, one million snails to be exact. The snails fill the mountain side and overflow into cities.

Astroboy wakes up in the middle of the desert, nearly drained of power and unable to remember how he got there. He is helped by Ali Baba, but in return Astro must battle 'The Sphinx'. This is not a real sphinx, but a robot which guards a desert tomb.

Zero Robot, a blend of Etheric Resin with Clear Plastic, can only be seen with polarized light. Fearless Fred Fenk uses Zero for robbery. Astro Boy once again battles another robot. Defeating Zero at a cost, Astro reassess his role in fighting villians.

Alien resembling aliens including the doctor of Ochanomizu and Higeyajiji emigrated from the stars that looked like the earth in emergency. However, the food crisis and humankind will begin attacking the aliens with cell shrink solution.

In a land called Shangri-Lee a dictator rose to power. Known to his enemies as the Mad Hatter he trusted no one. To solve this need to do everything himself he captured Dr Elefun. Dr Elefun was to make duplicates of the Mad Hatter. Astro Boy rescues Dr Elefun and the Spirit Machine is destroyed.

Crime knows no boundaries - not even the North Pole! Sharkey Dirk and his gang of cut-throats had become the Scourge of the Arctic! An avowed robot-hater, Sharkey foraged far and wide destroying every machine in his path. His hideout was a secret den situated right at the Pole (who would think to look for him there?)

'Lucky' Louie the Lug has slipped by the police at a space port and boarded the first commercial flight to the Moon. Astroboy pursues him seeking to recover stolen diamonds, but the liftoff is underway before he can apprehend the criminal. When meteors collide with the ship, Astro escapes in a damaged space raft with Louie, a little girl named Marvel, Radio Announcer 'Stark' Raving, socialite Mona Toujour and crooked insurance magnate 'Rocco' Gibraltor. They land on a strange asteroid which is a frozen vacuum by night, but has breathable air by day.

One day, excitable Mr. Pompous was relaxing at home when suddenly a mysterious ship crashed through his front door. Clearly the ship was something from the future.

After Dr I.M. Sinister and his 2 henchmen 'Red' and 'Mouse' escape from Sing Song Prison, they hide at the mining colony of Cross Island disguised as robots. The gang overpowers Dr Elefun, who is repairing the robot miners. As chance has it, one boy robot on the island was built by Dr Sinister. While holding Elefun at gunpoint, Sinister demands not only HIS robot but the use of parts from Astroboy, so he can build a super-robot capable of changing into an array of animals.

That priest was dying carving a single mark on the eyes of Christ decorated in the church. Apparently it seems to be a clue to teach the identity of the pirate who broke into the church. The same pirate begins to aim for beard hair that knew their secret.

Film producer Elia Belial plans to ruin Earth using an artificial sun.

Astro runs into two of his friends and stumbles upon an interesting flower. While Astro's friends want to pick it, Astro says to leave the flower alone. He then proceeds to tell the tale of this bizarre flower.

Young Koichi (Tommy Speed) prepares to enter a world race with his supersonic car, the Silver Comet.

Saturn (Baron Von Hoodwink), an evil robot kidnaps Princess Odette (Princess Lollipop), a robot swan who can turn back into her normal self when everyone's asleep. She runs away from Hullabaloo Land as Astro comes to her aid.

A robot centipede disguised as 47 wrestling robots causes havoc on a ship and in the ocean.

Garon, a giant cosmic robot lands on Earth as a meteor, then Astro Boy and the scientists reconstruct him. During a thunderstorm, Garon revives. A corrupt scientist tells Garon to reconstruct an island in the image of his home planet, also changing the atmosphere to match that of the planet, which is toxic to life on Earth.

Astronauts report seeing fireflies in space, but they are really gaseous beings led by the evil Toxor.

At the large space station Satellite R-45, Astro Boy discovers a pair of souvenir vendors hawking stolen wares.

At a beach Astro Boy spots a mysterious bottle with a note calling for rescue from an uncharted island called Sea Serpent Isle.

A mysterious epidemic causes people to drop into comas.

A strange robot demands that Astro Boy and Professor Ochanomizu accompany him to an unknown kingdom at the bottom of the sea.

Together with Dr. Jordan who ran away from under the president who plots world conquest, Atom who got into the underground tank fights the president. But the underground tank loses control and starts pushing towards the volcano.

An evil scientist who hates civilization named Dr. Ram (Don Tay) invents a robot called Atlas to destroy a village.

Time after time, mysterious forces destroy the huge underwater dam being built by the Institute of Science.

Dr. Fooler (Dr. I.Q. Plenty) pitches to some plant owners a machine that makes troublesome robots wacky and therefore harmless. The plant owners accept, and the device affects every robot in the city including Astro Boy.

Once a year, the citizens of Earth celebrate Memory Day and honor the memories of family members who have traveled far into the universe.

A president fears for his life, as the presidents of several other countries have all been attacked by Führer ZZZ (Secret Agent 3-Z).